In ArcGIS Pro there is a geoprocessing tool called Clip that cuts out a portion of a raster dataset, mosaic dataset, or image service layer (Clip—Data Management toolbox | ArcGIS Desktop ). I have a tile layer service in AGOL that I need to clip to individual states, 24 to be exact. Now, instead of doing the clipping in Pro and tiling 24 individual layers having a tool in AGOL, similar to Clip in Pro, would be very helpful. This would save a lot of time if you can do it if the layer is already online.
If the thought of just taking a layer of the U.S. and overlaying it over the tile layer and apply transparency the answer will be no, that looks really tacky.