I can see all of the features I've created thus far in the attribute table. The definition queries are clear. When I add the data to a new map, I can only see the spatial data when I'm zoomed out past 1:150,000 scale. That's the strangest part for me, because the minimum and maximum visible scale is nulled.
I don't know if it is a work space issue (I don't think it should be). I'm pulling the data from a .gdb with a lot of domains and subtype codes.
Hm, sounds like a spatial index problem. Are you using 10.1? Can you right click on the feature class, go to Properties > Indexes tab > and click Delete to delete the spatial index, then Create to create a new one?