I'm using Task Assistant Manager 10.5 and I'm following the instructions (http://desktop.arcgis.com/en/arcmap/latest/extensions/task-assistant-manager/hiding-the-initialization-progress-dialog-box.htm) but whenever I click Close, none of the changes I make are saved, apart from "Run as designer". I've tried as a regular user, as a local administrator, and as a domain administrator with no luck.
My investigation has found that apparently this was an issue in version 10.2 (https://community.esri.com/thread/80723) As per the initial user, "Run as designer" is the only setting that saves upon exit.
Windows 7 and 10
ArcGIS Desktop 10.5
Workflow Manager 10.5