Currently, the granting of Privileges in SDE is clumsy at best. It could be so much more fluid.
3 boxes. Available users, those with Read Only (Select), and Editors (SIUD). Simple highlight and then arrows to push between the boxes. There was an add on back in the 8.x days that had this. 10 fold easier than today.
SDE management. It's a thing in GIS.
The above is simply an idea from 15 years ago. By all means, do something different. Perhaps make it better. Add a list of Feature Classes/Tables/Other objects in a 4th box on the left.